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Zestoretic – A Prescription Medication with Lisinopril – Uses, Side Effects, and More


$1,02 per pill

Active Ingredient: Lisinopril / Hydrochlorothiazide

Dosage: 5/12.5g/mg

Overview of Zestoretic

Zestoretic is a prescription medication that is commonly prescribed to treat high blood pressure. It is a combination drug that contains two active ingredients: lisinopril and hydrochlorothiazide. This medication belongs to a class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and diuretics.

What is Zestoretic used for?

Zestoretic is primarily used to lower high blood pressure, also known as hypertension. It is often prescribed when lifestyle changes alone, such as exercise and diet modifications, are not sufficient to control blood pressure. By combining lisinopril and hydrochlorothiazide, Zestoretic helps to relax blood vessels while removing excess fluid from the body, ultimately reducing the overall pressure on the heart and improving blood flow.

Key ingredients

1. Lisinopril: This component of Zestoretic is an ACE inhibitor, which works by blocking the production of a hormone called angiotensin II. By doing so, it helps to relax and widen blood vessels, allowing blood to flow more easily. This reduction in blood vessel constriction helps in lowering blood pressure.

2. Hydrochlorothiazide: This ingredient belongs to a class of medications known as diuretics or “water pills.” It helps the body get rid of excess salt and water by increasing urine production. By removing excess fluid from the body, hydrochlorothiazide helps decrease the overall volume of blood, thus lowering blood pressure.

How to take Zestoretic?

It is essential to follow your healthcare provider’s instructions when taking Zestoretic. The medication typically comes in tablet form and is taken orally with or without food. The dosage and frequency will be determined by your doctor, based on your medical condition, response to treatment, and other factors.

It is crucial to take Zestoretic regularly to achieve the best results. Do not stop taking the medication abruptly without consulting your doctor, even if you feel well. Suddenly stopping Zestoretic may worsen your condition.

Common side effects

As with any medication, Zestoretic may cause certain side effects. Some common side effects that have been reported include:

  • Dizziness
  • Headache
  • Dry cough
  • Tiredness
  • Stomach upset

If you experience any persistent or severe side effects, it is important to contact your doctor immediately.


Zestoretic is a well-known prescription medication used to treat high blood pressure. It combines the benefits of lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. By lowering blood pressure and reducing the workload on the heart, Zestoretic helps promote better cardiovascular health. If you have been prescribed Zestoretic, make sure to follow your doctor’s instructions and report any concerning side effects.

2. Indications for Use

Zestoretic is primarily prescribed for the treatment of hypertension (high blood pressure) in patients who haven’t responded sufficiently to a single antihypertensive drug.

2.1 Hypertension

Hypertension, also known as high blood pressure, is a chronic medical condition in which the force of blood against the artery walls is consistently too high. If left untreated or uncontrolled, hypertension can lead to various serious health complications, such as heart disease, stroke, and kidney problems.

Zestoretic is particularly beneficial for patients with hypertension for the following reasons:

  • Combination Therapy: Zestoretic combines two effective active ingredients, lisinopril and hydrochlorothiazide, in one medication, providing a more convenient treatment option for patients who require both drugs to control their blood pressure.
  • Enhanced Blood Pressure Control: Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, works by dilating blood vessels to reduce blood pressure. Hydrochlorothiazide is a diuretic that promotes the removal of excess fluid from the body, further helping to lower blood pressure.
  • Synergistic Effects: The combination of lisinopril and hydrochlorothiazide in Zestoretic has been shown to have synergistic effects, where their combined action produces a more potent antihypertensive effect compared to using each drug alone.
  • Reduced Side Effects: By combining the two drugs, Zestoretic can achieve blood pressure control with lower doses of each individual drug, minimizing the risk of adverse effects that may occur at higher doses.

Therefore, Zestoretic is a valuable treatment option for patients with hypertension who require combination therapy to achieve adequate blood pressure control.

If you’re interested in learning more about the detailed mechanism of action of lisinopril and hydrochlorothiazide, you can visit the following authoritative sources:

  1. National Center for Biotechnology Information (NCBI) – Lisinopril
  2. National Center for Biotechnology Information (NCBI) – Hydrochlorothiazide

3. Indications and Usage of Zestoretic

Zestoretic is primarily prescribed for the treatment of hypertension, or high blood pressure, in adults. It combines the benefits of two active ingredients, lisinopril and hydrochlorothiazide, to effectively lower blood pressure levels.

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that helps relax blood vessels, allowing for smoother blood flow and reduced blood pressure. Hydrochlorothiazide, on the other hand, is a thiazide diuretic that helps eliminate excess salt and water from the body, further aiding in blood pressure reduction.

The combination of these two medications in Zestoretic provides a dual action approach to managing hypertension, making it an effective option for many patients.

Conditions Treated by Zestoretic

Zestoretic is commonly prescribed for individuals with the following conditions:

  • Hypertension (high blood pressure)
  • Chronic kidney disease

By effectively lowering blood pressure, Zestoretic helps reduce the risk of serious complications associated with hypertension, such as heart attack, stroke, and kidney problems.

How to Take Zestoretic

Zestoretic is available in tablet form and should be taken orally as directed by your healthcare provider. The dosage may vary depending on individual needs and medical condition. It is important to follow the prescribed dosage and frequency of administration.

It is generally recommended to take Zestoretic with or without food, but it should be taken consistently at the same time each day to maintain consistent blood pressure control.

If you miss a dose, take it as soon as you remember. However, if it is close to the time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible Side Effects

Like all medications, Zestoretic may cause side effects in some individuals. Common side effects may include:

  • Dizziness
  • Cough
  • Headache
  • Fatigue
  • Nausea

These side effects are usually mild and temporary. However, if they persist or worsen, it is important to consult your healthcare provider. It is also essential to be aware of the signs of a serious allergic reaction, such as rash, itching, swelling, severe dizziness, and difficulty breathing. In such cases, seek immediate medical attention.

It is important to discuss any existing medical conditions and medications with your healthcare provider before starting Zestoretic to ensure its safe and appropriate use.

For more information on Zestoretic, consult reliable sources such as the U.S. Food and Drug Administration (FDA) or speak to your healthcare provider.

4. How Does Zestoretic Work?

Zestoretic is a combination medication that works by lowering blood pressure and reducing the workload on the heart. It contains two active ingredients: lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide, a diuretic.

Lisinopril: Lisinopril works by inhibiting the ACE enzyme, which plays a crucial role in the production of a hormone called angiotensin II. Angiotensin II is responsible for narrowing the blood vessels, causing an increase in blood pressure. By blocking the action of ACE, lisinopril helps relax and widen the blood vessels, allowing blood to flow more easily and lowering blood pressure.

Lisinopril also helps to reduce the amount of water and salt in the body, which further helps in lowering blood pressure.

Hydrochlorothiazide: Hydrochlorothiazide is a diuretic, commonly known as a water pill. It works by increasing the rate at which the kidneys remove excess water and salt from the body through urine. By increasing urine production, hydrochlorothiazide helps to reduce fluid retention and lower blood pressure.

When lisinopril and hydrochlorothiazide are combined in Zestoretic, they complement each other’s actions, resulting in a more effective blood pressure-lowering effect.

It is important to note that Zestoretic should be taken as prescribed by your healthcare provider. Do not increase or decrease the dose without consulting your doctor.

Key Points about How Zestoretic Works:
Lisinopril Hydrochlorothiazide
Inhibits the ACE enzyme to relax and widen blood vessels Increases urine production to reduce fluid retention and lower blood pressure
Reduces water and salt in the body

In summary, Zestoretic combines the actions of lisinopril and hydrochlorothiazide to effectively lower blood pressure and reduce the workload on the heart. These medications work together to relax blood vessels, increase urine production, and decrease fluid retention. Remember to follow your doctor’s instructions and take Zestoretic as prescribed for optimal results.

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For more information about Zestoretic, you may visit the official Zestoretic website or consult a reputable medical source like the Mayo Clinic.

5. Common side effects of Zestoretic

While Zestoretic can be a helpful medication for managing hypertension and heart failure, like any prescription drug, it may cause some side effects. It is essential to be aware of these potential side effects and learn how to recognize them. It is important to note that not everyone who takes Zestoretic will experience side effects, and some side effects may be more common than others. If you are concerned about any potential side effects, it is recommended that you consult with your healthcare provider.

5.1 Dizziness and lightheadedness

One common side effect of Zestoretic is dizziness or lightheadedness. Some people may experience a feeling of unsteadiness or faintness when they first start taking the medication. If you notice such symptoms, it is crucial to avoid driving or operating heavy machinery until you are sure of how the medication affects you. It is recommended to sit or lie down when feeling dizzy and rise slowly from a seated or lying position to minimize this side effect.

5.2 Cough

Another possible side effect of Zestoretic is a dry, persistent cough. This cough may be more common in patients who take ACE inhibitors, such as lisinopril, found in Zestoretic. If you develop a bothersome or persistent cough, it is important to inform your healthcare provider. They may be able to recommend alternative medications or suggest remedies to alleviate the cough.

5.3 Fatigue

Some individuals taking Zestoretic may experience feelings of tiredness or fatigue. This side effect might affect daily activities and decrease overall energy levels. It is recommended to prioritize rest and ensure an adequate amount of sleep while taking the medication. If the fatigue persists or becomes severe, consult your healthcare provider for further evaluation.

5.4 Upset stomach

Occasionally, Zestoretic may cause gastrointestinal side effects such as nausea, stomach pain, or diarrhea. It is important to take the medication with food to minimize the risk of upset stomach. If these symptoms persist or become severe, seek medical attention to prevent dehydration or other complications.

5.5 Orthostatic hypotension

Zestoretic can sometimes result in a sudden drop in blood pressure when standing up, known as orthostatic hypotension. This may cause dizziness, lightheadedness, or even fainting. To reduce the risk of orthostatic hypotension, it is recommended to rise slowly from a seated or lying position. If you experience symptoms of orthostatic hypotension, it is important to notify your healthcare provider.

5.6 Allergic reactions

Although rare, some individuals may experience an allergic reaction to Zestoretic. Signs of an allergic reaction may include rash, itching, swelling of the face, lips, or tongue, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.

These are not the only possible side effects of Zestoretic, and individual experiences may vary. If you have any concerns or questions about the side effects of Zestoretic, please consult your healthcare provider for more information.


$1,02 per pill

Active Ingredient: Lisinopril / Hydrochlorothiazide

Dosage: 5/12.5g/mg

Zestoretic: Side Effects and Precautions

When considering taking any medication, it is crucial to be aware of its potential side effects and necessary precautions. Zestoretic, a prescription medication that combines two active ingredients – lisinopril and hydrochlorothiazide – is no exception. Below, we will discuss the possible side effects of Zestoretic and precautions to take while using it.

Possible Side Effects of Zestoretic:

1. Dizziness: It is common to experience dizziness while taking Zestoretic. Ensure you stand up slowly from a sitting or lying position to avoid sudden drops in blood pressure. If you experience persistent dizziness, consult your healthcare provider.

2. Cough: Zestoretic may cause a persistent dry cough in some individuals. If the cough becomes bothersome or persists, notify your doctor.

3. Fatigue: Feeling tired or fatigued is a potential side effect of Zestoretic. If you find yourself excessively tired while on this medication, discuss it with your healthcare provider.

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4. Headache: Headaches may occur while taking Zestoretic. If the headache is severe or persistent, seek medical advice.

5. Nausea: Some individuals may experience nausea while using Zestoretic. If nausea becomes severe or interferes with your daily activities, contact your doctor.

6. Rash or Itching: Zestoretic can rarely cause rash or itching. If you notice any skin changes or persistent itching, consult your healthcare provider immediately.

It is crucial to remember that these side effects are possible but not guaranteed for every individual taking Zestoretic. If you experience any unusual or severe symptoms, contact your healthcare provider for guidance.

Precautions while using Zestoretic:

1. Allergies: Inform your doctor about any allergies you may have, especially if you are allergic to any medications, including ACE inhibitors like lisinopril or diuretics such as hydrochlorothiazide. This information will help your healthcare provider assess potential risks before prescribing Zestoretic.

2. Kidney Problems: If you have a history of kidney disease or impaired renal function, use Zestoretic with caution. Regular monitoring of kidney function is essential while on this medication.

3. Pregnancy and Breastfeeding: Zestoretic is not recommended for use during pregnancy or while breastfeeding. It may cause harm to the unborn baby or pass into breast milk, potentially harming the nursing infant. Consult your doctor for alternative options.

4. Other Medical Conditions: Inform your healthcare provider if you have any other medical conditions, such as liver disease, heart problems, or diabetes. These conditions may interact with Zestoretic and require close monitoring or adjustment of the dosage.

5. Drug Interactions: Zestoretic may interact with certain medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), potassium supplements, or other medications that lower blood pressure. It is important to inform your doctor about all the medications you are currently taking to avoid potential interactions.

Remember, this is not an exhaustive list of precautions. Always follow the advice of your healthcare provider and read the medication guide provided with Zestoretic to ensure safe and effective use.

Sources: Mayo Clinic, RxList, WebMD

7. Potential side effects of Zestoretic

While Zestoretic is an effective medication for treating high blood pressure, it is important to be aware of the potential side effects that may arise. It is important to note that not all individuals will experience these side effects, and some may experience different symptoms not listed here. It is always advisable to consult a healthcare professional for personalized advice and guidance.

Common side effects

Some common side effects that have been reported in patients taking Zestoretic include:

  • Dizziness or lightheadedness
  • Cough
  • Fatigue or weakness
  • Headache
  • Upset stomach or diarrhea

If any of these side effects become severe or persistent, it is important to seek medical attention.

Serious side effects

While rare, Zestoretic may cause more serious side effects. These may include:

  • Allergic reactions such as rash, itching, or swelling of the face, lips, tongue, or throat
  • Fainting or feeling light-headed
  • Chest pain or tightness
  • Significant decrease in urine production
  • Difficulty breathing or swallowing
  • Yellowing of the skin or eyes (jaundice)

If any of these severe side effects occur, immediate medical attention should be sought.


It is important to discuss your medical history and any current medications with your doctor before starting Zestoretic. Certain conditions or medications may interact with Zestoretic and increase the risk of side effects. It is particularly important to inform your healthcare provider if you have:

  • History of angioedema
  • Liver or kidney disease
  • Diabetes
  • Heart disease or congestive heart failure
  • Systemic lupus erythematosus (SLE)
  • Fluid or electrolyte imbalances

Your healthcare provider will be able to determine whether Zestoretic is appropriate for you and monitor your progress while taking the medication.

Remember, this is not an exhaustive list of side effects. If you experience any symptoms that are unusual or concerning while taking Zestoretic, it is important to seek medical attention promptly.

For more information on Zestoretic and its potential side effects, you can visit the or RxList websites.