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Lisinopril – Overview, Uses, and Side Effects for High Blood Pressure Treatment


$1,33 per pill

Active Ingredient: Hydrochlorothiazide

Dosage: 10mg, 5mg

General overview of Lisinopril:

Lisinopril, also known by the brand names Prinivil and Zestril, is a commonly prescribed medication used to treat high blood pressure (hypertension). It belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors, which work by relaxing blood vessels to improve blood flow and reduce hypertension.

Originally developed by Merck & Co., Lisinopril was approved by the U.S. Food and Drug Administration (FDA) in 1987 and has since become a staple in the treatment of high blood pressure. It is available in tablet form and is typically taken once a day.

One of the key benefits of Lisinopril is its effectiveness in lowering blood pressure, which can help reduce the risk of heart attack, stroke, and other cardiovascular complications. It is often prescribed to patients with hypertension as a first-line treatment due to its proven track record and relatively low incidence of side effects.

Common side effects of Lisinopril may include dizziness, headache, cough, and fatigue. However, serious side effects such as allergic reactions are rare but possible. It is important for patients to follow their healthcare provider’s instructions carefully when taking Lisinopril and to report any concerning symptoms promptly.


Lisinopril Dosage

When it comes to Lisinopril dosage, it is important to follow the prescribed instructions from your healthcare provider. The typical starting dose for treating high blood pressure is 10 mg once a day. However, this dosage may vary depending on individual factors such as age, medical condition, and response to treatment.


Your doctor may adjust your Lisinopril dosage gradually based on your blood pressure readings. This process is known as titration and is aimed at finding the most effective dose for you. It is essential to follow your healthcare provider’s guidance and not to change the dosage on your own.

Maximum Dosage

The maximum recommended dose of Lisinopril for treating hypertension is typically around 40 mg per day. In some cases, higher doses may be prescribed for specific medical conditions under close medical supervision.

Missed Dose

If you miss a dose of Lisinopril, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.


If you suspect an overdose of Lisinopril or experience symptoms such as dizziness, fainting, or difficulty breathing, seek immediate medical attention. An overdose of Lisinopril can be serious and should be treated promptly by healthcare professionals.

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$1,33 per pill

Active Ingredient: Hydrochlorothiazide

Dosage: 10mg, 5mg

Lisinopril Dosage and Administration

Lisinopril is typically taken once a day, usually in the morning. It can be taken with or without food, but it should be taken consistently each day to maintain steady levels in the body. The dosage of Lisinopril will vary depending on the condition being treated.

For High Blood Pressure:

  • The usual starting dose is 10 mg once a day.
  • For maintenance, the dose can be increased to a maximum of 40 mg per day.
  • It may take several weeks for Lisinopril to reach its full effect, so patients should continue to take it even if they feel well.
  • It is important not to suddenly stop taking Lisinopril without consulting a healthcare provider, as this can lead to a rebound increase in blood pressure.

For Heart Failure:

  • The initial dose is usually 5 mg once a day.
  • Patients may be titrated to a target dose of 20 mg once a day, depending on tolerability.
  • Lisinopril has been shown to improve survival and reduce hospitalizations in patients with heart failure.

For Acute Myocardial Infarction:

  • A starting dose of 5 mg within the first 24 hours of a heart attack, followed by 5 mg after 24 hours, 10 mg after 48 hours, and then 10 mg once a day thereafter.
  • Lisinopril can help improve outcomes after a heart attack and reduce the risk of further heart-related events.

It is important for patients to follow the prescribed dosage and administration instructions provided by their healthcare provider. Regular monitoring of blood pressure and kidney function may be necessary while taking Lisinopril to ensure optimal treatment outcomes.

Lisinopril Side Effects

Common Side Effects

Some of the common side effects of Lisinopril include dizziness, headache, cough, and nausea. These side effects are usually mild and may improve as your body adjusts to the medication. It is important to inform your healthcare provider if these side effects persist or worsen.

Serious Side Effects

While less common, Lisinopril can also cause serious side effects that require immediate medical attention. These include symptoms such as fainting, chest pain, trouble breathing, or swelling of the face, lips, throat, or tongue. If you experience any of these symptoms, seek medical help right away.

Allergic Reactions

It is possible to have an allergic reaction to Lisinopril, although this is rare. Signs of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you suspect an allergic reaction, stop taking the medication and contact your healthcare provider immediately.

Interactions with Other Medications

Before taking Lisinopril, it is important to inform your healthcare provider about all the medications you are currently taking, including prescription and over-the-counter drugs, as well as any herbal supplements. Certain medications, such as diuretics or NSAIDs, may interact with Lisinopril and lead to potential side effects or reduced effectiveness of the medication.

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In conclusion, while Lisinopril is an effective medication for treating high blood pressure, it is important to be aware of the potential side effects and interactions with other medications. By staying informed and communicating with your healthcare provider, you can minimize the risks and maximize the benefits of taking Lisinopril.

Lisinopril dosage and administration

When it comes to taking Lisinopril, it’s important to follow the prescribed dosage and administration instructions provided by your healthcare provider. This medication is typically taken orally once a day, with or without food. It’s best to take Lisinopril at the same time each day for maximum effectiveness.

The usual starting dose for treating high blood pressure with Lisinopril is usually 10 mg once daily. However, the dosage may vary depending on the individual’s condition and response to the medication. Your doctor may adjust the dosage gradually to achieve the desired blood pressure control.

Lisinopril dosage guidelines
Condition Starting dose Maximum dose
High blood pressure 10 mg once daily 40 mg once daily
Heart failure 2.5-5 mg once daily 40 mg once daily
Post-heart attack 5 mg once daily 35 mg twice daily

It’s essential not to skip any doses of Lisinopril and to continue taking the medication even if you feel well. Abruptly stopping Lisinopril can lead to a sudden increase in blood pressure, which can be harmful.

Regular monitoring of blood pressure levels is crucial while taking Lisinopril to ensure that the medication is effectively controlling hypertension. Your doctor may recommend periodic blood tests to check kidney function, as Lisinopril can affect renal function in some individuals.

Remember that Lisinopril is just one part of a comprehensive treatment plan for high blood pressure or other conditions. Lifestyle modifications such as a healthy diet, regular exercise, and weight management are also essential in managing these conditions effectively.


$1,33 per pill

Active Ingredient: Hydrochlorothiazide

Dosage: 10mg, 5mg

Lisinopril side effects

Lisinopril, like any medication, may cause side effects in some individuals. It is important to be aware of these potential side effects when taking this medication. Here are some common side effects of Lisinopril:

  • Cough: A persistent, dry cough is a common side effect of Lisinopril. If you experience a cough that does not go away, consult your healthcare provider.
  • Dizziness: Some individuals may experience dizziness or lightheadedness when taking Lisinopril. It is important to be cautious when standing up quickly to avoid falling.
  • Fatigue: Feeling tired or fatigued is another possible side effect of Lisinopril. If you experience excessive tiredness, talk to your doctor.
  • Headache: Headaches are a common side effect of Lisinopril. If you have severe or persistent headaches, seek medical advice.
  • Increased potassium levels: Lisinopril can sometimes cause elevated levels of potassium in the blood. Your doctor may monitor your potassium levels while taking this medication.
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Less common Lisinopril side effects

In addition to the common side effects listed above, some individuals may experience less common side effects when taking Lisinopril. These may include:

  • Rash: A rash or itching may occur in some individuals taking Lisinopril. Seek medical attention if you experience a severe rash.
  • Angioedema: While rare, Lisinopril can cause a severe allergic reaction called angioedema, which presents as swelling in the face, lips, or throat. This requires immediate medical attention.
  • Impotence: Some men may experience difficulty achieving or maintaining an erection while taking Lisinopril. Discuss any sexual side effects with your doctor.
  • Pancreatitis: In rare cases, Lisinopril may be associated with pancreatitis. If you experience severe abdominal pain, seek medical help immediately.

If you have any concerns about the side effects of Lisinopril, consult your healthcare provider for guidance and support.

7. Lisinopril Interactions

It is crucial to be aware of potential interactions Lisinopril may have with other medications or substances. These interactions can impact the effectiveness of Lisinopril or lead to adverse reactions. Here are some key points to consider:

Medications that may interact with Lisinopril:

  • Ace Inhibitors: Combining Lisinopril with other Ace Inhibitors can increase the risk of hyperkalemia.
  • Potassium-Sparing Diuretics: Concurrent use of Lisinopril with these diuretics can lead to high levels of potassium in the blood.
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs): NSAIDs may reduce the effectiveness of Lisinopril in lowering blood pressure.

Substances to avoid when taking Lisinopril:

  • Alcohol: Drinking alcohol while on Lisinopril may worsen side effects like dizziness or lightheadedness.
  • Potassium Supplements: High doses of potassium supplements can cause dangerous levels of potassium when combined with Lisinopril.

Warnings and precautions:

It is essential to inform your healthcare provider of all medications, supplements, and herbal products you are taking before starting Lisinopril. This helps prevent potential interactions and ensures your safety while on the medication.

According to a study published in the National Center for Biotechnology Information, Lisinopril’s interactions with certain medications can impact its efficacy.

Statistics on Lisinopril interactions:

Medication Interaction
Ace Inhibitors Increased risk of hyperkalemia
Potassium-Sparing Diuretics High potassium levels in the blood
NSAIDs Reduced effectiveness of Lisinopril